I am not sure of the connotation of your question as it relates to Check 21. Are you asking if an item that has requirement for 2 sigs is presented as a substitute check? I beleive the answer is that it should not be any different. If you are asking as it relates to an image presentment, you will either have automated software to review the image and work with an account profile that identifies the need for 2 sigs. I don't know if this helps but if yo provide more specifics, I will try to further respond.