If your mainframe rolls up to your call report, well yes of course. You'll find that during a data integrity exam, the examiner will compare your CRA LR (or HMDA LAR) to what you have on your system. It should match the call report.
There are some changes I don't make (ie address changes on doc systems) but all others are changed on the LR and the main system the bank uses.
To not make these changes means you've covered your CRA bumm
but left the comptroller hanging out with an error filled call report. This is punishable by fines and jail time if it's serious (this wouldn't be, but that's neither here nor there). My personal ethics protect my bumm....but also the bank's bumm, which includes the folks responsible for filing the call report