The funny thing about OFAC is that you are technically "responsible" for everything that you do that could potentially come into contact with one of the listed entities, countries, or individuals. Considering that, your institution has to determine how much risk it is willing to take based on the cost of decreasing and hopefully eliminating that risk.
Where wire transfers are concerned, most financial institutions I have talked to have generally checked the names regardless of whether they were an originator, intermediary or beneficiary.
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I have many opinions; some are good, some are bad, and some don't contradict.