We have a customer that we believe is the victim of a scam where they believe they are helping their "girlfriend" access her inheritance and in return they will receive part of the inheritance. The customer fully believes the scam and has wired money out in relation to this scam. We do have name of the girlfriend, suspect, and the wire was over $5,000. Would this warrant a SAR?

Yes, if you have a name - real or not.

Wasn't this a red flag when the wire was first originated?

Those facts may not have been known until after the wire was sent and the customer figured out they were scammed.