Reg O doesn't, but 23B (Reg W) might, if that insider is also an affiliate.
A word of caution. If you will be doing business with an insider or any of his companies, make sure that they are on equal terms (or favorable to the bank) as what you can get from a non-insider. For example, if you are renting an office from the insider, and market rents are $500 for a comparable space, the bank should be paying $500 or less. Whatever you do, document, document, document. The examiners hate to see the bank being taken advantage of by an insider.
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You gain education by reading the fine print. You gain experience by not.