There is nothing wrong with lending to people with ITINs. However, I have seen a number of banks get into deep fair lending trouble with "special programs" geared to people with ITINs. It cost them dearly in legal fees, research and administrative expense digging themselves out of the hole. Some successfully and some not so much. Trust me, I have worked with a lot of banks in Texas.
If you have a special program for people with ITINs, likely they are some sort of protected class. So, saying you will make loans under this "special program" and then have totally different criteria for people with and without an ITIN gets into some really hard to justify disparate impact issues.
I suggest that you tread lightly and make sure you go into such a program with your eyes wide open. If you are lending to people with ITINs because you know or at least suspect they are undocumented, then you also need to consider the ramifications of foreclosure, if your borrowers are subsequently deported and quit paying on the loan.
It can be done, but do it carefully if you are considering a "special program".
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