Used to be 36% then 38% and now 40% some even 45%. Many home equity lenders are now using 50% as their threshold!
For residential mortgage lenders, industry standards, secondary market standards, risk tolerances all play into the determination. For consumer lenders, with less of a secondary market presence, the individual risk tolerance of the lender is important.
Think about it in reverse though to understand where income can be allocated. Starting with a pool of 100% of your income: 15-20% can be allocated to federal income tax; 3-5% to state income tax; then other living expenses such as: insurance (auto, health, life, ex housing)can easily eat up 10% of gross income; food; utilities (elec, water, natural gas, cable phone, cell phone, internet); GAS!; medical copays; clothing; etc etc etc can easily all add up to 50% of income or greater, depending on the number of members in a household and their lifecycle.