Nice post, AML.
KC, you should also look at the destinations in terms of "high risk," in terms of U.S. as well as foreign geographies. Identifying HIFCAs is relatively easy. Identifying HIDTAs is more difficult and I would probably make the attempt only on recurring destinations rather than one-off transactions.
You can make a career out of sorting wires and still find nothing. First of all, focus on whether the wire is legitimately explained by the customer's business activity and then spend your blood and treasure on those where the answer is not so clear.
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In this world you must be oh so smart or oh so pleasant. Well, for years I was smart. I recommend pleasant.